Logo Tafalgie Therapeutics

Project chronology & history

a number of key stages in this project, extending from research to development

Tafalgie Therapeutics came into being in October 2020.

This company brings together researchers and entrepreneurs with the shared aim of valorizing more than 10 years of fundamental research conducted by Dr. Aziz Moqrich and his team. 

This work has been the subject of numerous publications and an international patent has been filed (by the SATT on behalf of the CNRS and AMU) concerning the use of a new protein as a potential analgesic for treating inflammatory and neuropathic pain.

the key stages :

1939:

Discovery of the type C low-threshold mechanoreceptor neuron class (C-LTMR) by Yngve Zotterman

2007:

Identification of the TAFA4 protein as a specific molecular marker of C-LTMR sensory neurons

2010:

Elucidation, by the team of Aziz Moqrich, of the role of the TAFA4 protein in pain gate control

2013:

Filing of a first patent linked to TAFA4 by Aziz Moqrich

2021/2022:

Filing of two new product patents in December 2021 and May 2022 (for polypeptide derived from TAFA4) by Tafalgie Therapeutics and the CNRS

2005-2006

Creation of the Team ‘Chronic Pain’.

Molecular and cellular mechanisms” team by Dr. Aziz Moqrich from the IBDM, and Dr. Stephane Gaillard, who joined this new team

2020

Sublicense exploitation agreement 

// Satt Sud-Est (SEE).

 

2019-2020

Creation of the society Tafalgie Therapeutics.

Completion of the Tafalgie Therapeutics founders by the arrival of Laurent Labatut and the establishment of a support team

and now ? 2023 ?

The company begins operating, with the performance of preclinical studies…

R&D activities, regulatory activities, the establishment of a scientific advisory board and efforts to obtain financial support

alain eschalier

Professor Emeritus
Professor Emeritus at the University of Aix Marseille and former Professor at McGill University, Montreal, Canada

Alain Eschalier (MD, PhD, PharmD) is Professor Emeritus of Medical Pharmacology at the University of Clermont, Auvergne, France and is board-certified in pharmacology, psychiatry and human biology.

 

  • He is also the former head of the Medical Pharmacology Department of the Faculty of Medicine and the University Hospital of Clermont-Ferrand.
  • He was the founding director of several Inserm research units focusing on the fundamental and clinical pharmacology of pain, participated in the creation of two start-up companies and was a consultant for several companies.
  • He has chaired the Analgesia Institute since 2014, and has chaired the biomedical and public health research committee (CRBSP) and the scientific council of the French Society of Pharmacology and Therapeutics (SFPT) since 2015.
Eschalier is investigating the preclinical and clinical pharmacology of analgesics and the pathophysiology of chronic pain.

Clifford j.woolf

Professor of Neurology & neurobiology
Dr. Clifford J. Woolf is Professor of neurology and neurobiology at Harvard Medical School (HMS) and Director of the F.M Kirby Neurobiology Center at Boston Children’s Hospital. His work has greatly contributed to our understanding of pain.

Dr. Clifford J. Woolf was born in South Africa, where he earned his MB, BCh, and PhD degrees. He then moved to London and became Professor of Neurobiology at University College London. In 1997, he was recruited by the Massachusetts General Hospital and Harvard Medical School to serve as the Richard J. Kitz Professor of Anesthesiology Research. 

  • In 2010 he was named Director of the F. M. Kirby Neurobiology Center at Boston Children’s Hospital and became Professor of Neurology and Neurobiology at HMS. He holds faculty positions at both the Department of Neurobiology at Harvard Medical School and the Harvard Stem Cell Institute. Over his career, Dr. Woolf has received many honors and prizes. 

 

  •  In 2020, he was elected a fellow of the American Academy of Arts and Sciences and was received an honorary degree from the University of Lausanne, Switzerland. He received a Gill Distinguished Scientist award and the Reeve-Irvine medal in 2017, the Kerr award from the American Pain Society in 2015.
  • Woolf was appointed to the Board of Scientific Councilors of the National Institute of Neurological Diseases and Stroke from 2015 to 2019 and is currently a member of the NIH HEAL Partnership Committee for the development of new treatments for pain and addiction. He has published over 300 research papers on molecular, cellular, and systems neurobiology and has a portfolio of more than 30 issued patents. 

His research focuses on the roles of the functional, chemical and structural plasticity of neurons in both the normal adaptive functions of nervous systems and in the maladaptive changes contributing to neurological diseases. He focuses, in particular, on pain, regeneration and neurodegeneration and on the exploitation of stem cell-derived neurons for disease modeling and drug screening.

Jean-louis kraus

Professor Emeritus
Professor Emeritus at the University of Aix Marseille and former Professor at McGill University, Montreal, Canada

Jean-Louis Kraus is Professor Emeritus at the University of Aix Marseille, France and was formerly Professor at McGill University in Montreal, Canada.

  • He has an extensive experience in the creation of biotechnology start-ups, such as Trophos (which was acquired by Roche, Switzerland), BioPharmed and Planktovie. 
  • His international reputation in medicinal chemistry has resulted in his invitation to serve as a member of numerous scientific research evaluation committees (Inserm, FRM, Sidaction, ANRS) in France and abroad, and as a senior scientist at Biochem Pharma (Canada). He has also served as a member of various advisory committees for strategic private investments and was responsible for research & development as a member of the Board of Marseille University (creation of Protisvalor).

Prof. Kraus’s considerable experience and commercial success have enabled him to develop extensive networks during the course of his career.

Jon levine

Neuroscientist
Jon David Levine is an American neuroscientist known for his research on pain and analgesia, particularly in the area of placebo studies. He is Professor of medicine, oral and maxillofacial surgery, and neurosciences at the University of California, San Francisco (UCSF).

• Prof. Levine’s research focuses on pain and analgesia, including, in particular, the mechanism by which the placebo effect can relieve pain. In 1978, he published an influential study showing that placebo analgesia could be blocked by the opioid antagonist naloxone.

Levine’s studies were the starting point for “placebo biology”.

ardem patapoutian

Honorary President
Ardem Patapoutian is a molecular biologist specializing in sensory transduction.

His research has led to the identification of new ion channels and receptors activated by temperature, mechanical force, and increases in cell volume. His laboratory has shown that these ion channels play crucial roles in sensing temperature, touch, and pain, in proprioception, and in regulating vascular tone.

Patapoutian was born in Lebanon in 1967 and attended the American University of Beirut for one year before emigrating to The United States in 1986. He became a US citizen, graduating from UCLA in 1990 and obtaining a PhD from Caltech in 996, for his work in the laboratory of Dr. Barbara Wold.

Following his postdoctoral work with Dr. Lou Reichardt at UCSF, he joined the Scripps Research Institute faculty in 2000, and is currently Professor in the Department of Neuroscience. He also held a position at the Genomics Institute of The Novartis Research Foundation from 2000-2014.

Patapoutian was awarded the Young Investigator Award from the Society for Neuroscience in 2006 and was named an Investigator of the Howard Hughes Medical Institute in 2014.

He is a fellow of the American Association for the Advancement of Science (2016), a member of the National Academy of Sciences (2017) and a member of the American Academy of Arts and Sciences (2020). He received the 2017 Alden Spencer Award from Columbia University (together with David Ginty), the 2019 Rosenstiel Award for Distinguished Work in Basic Medical Research (with David Julius), the 2020 Kavli Prize in Neuroscience (with David Julius), the 2021 BBVA Foundation Frontiers of Knowledge Award (shared with David Julius), and the 2021 Nobel Prize in Physiology or Medicine (with David Julius).

2021 : Nobel Prize in Physiology or Medicine (with David Julius)